Tony Vitayakul, a RTP detective in Thailand, subdues a group of human traffickers in pretext of “buying” a Thai girl. Tony collects information about the ship used to transport trafficked girls and its destination, where he learns that Viktor Dragovic, a Serbian mobster, will be there to receive the shipment. Meanwhile, Nick Cassidy, a NPD detective in Newark, New Jersey, discovers that Dragovic is in New Jersey. Cassidy and his superior officer Captain Costello brief a group of cops on Dragovic, revealing that Dragovic is a major player in human trafficking worldwide. As the ship carrying Dragovic’s container approaches the US, Cassidy and his men prepare to intercept it at the dock. When the ship arrives, Dragovic discovers the trafficked women have died during the transport. The ship’s captain is held responsible, tortured and shot in the head. When the police move in, a shootout erupts in which Cassidy fatally shoots Dragovic’s youngest son Andre in self-defense and Dragovic gets arrested.

While in custody, Dragovic arranges an attack on Cassidy’s family in which Cassidy’s wife and daughter Sofia are killed, but Cassidy survives. Costello and Reed, an FBI agent, visits Cassidy in the hospital and tell him that Dragovic has fled the US. After they leave, Cassidy steals clothing and an opiate drug before leaving the hospital. Cassidy gets his guns and goes to the restaurant of Dragovic’s attorney. After forcing the attorney to reveal Dragovic’s whereabouts, Cassidy shoots him and blows up the restaurant. In Cambodia, Senator Khat warns Dragovic that unless he leaves the country immediately, Dragovic will be arrested and extradited to the US. Dragovic blackmails the Senator into giving him two weeks to put his affairs in order and flee. Cassidy travels to Thailand in pursuit of Dragovic. Believing that Cassidy has experienced a nervous breakdown, the US authorities have sent Reed to detain him. Vitayakul and his partner Nung are ordered to assist with the arrest. At Suvarnabhumi Airport, Cassidy escapes from the police. Reed, who has been bribed by Dragovic, kills Nung and blames Cassidy for the murder. Vitayakul pursues Cassidy through the streets, but is unable to capture him. Cassidy reaches a nightclub in Poipet. After torturing one of Dragovic’s men, Cassidy discovers the location of Dragovic’s current operations. Vitayakul and Reed arrive at the nightclub to arrest Cassidy. After fighting with Vitayakul, an injured Cassidy escapes again. Reed uses the timing of a call on Vitayakul’s cell phone to discover an informant: Vitayakul’s girlfriend Min. While Cassidy is attempting to locate Dragovic’s illegitimate son Janko, who oversees Dragovic’s human trafficking business in Southeast Asia, a shootout erupts between Cassidy and Janko’s men. Janko flees the warehouse, but he is killed by his half-brothers Ivan and Goran Dragovic. Vitayakul learns the truth about his partner’s death, where he kills Reed instead. Janko reveals his father’s location before dying. The next day, Cassidy and Vitayakul team up and storm Dragovic’s compound. Ivan is holding Min at gunpoint, but Vitayakul shoots him. Cassidy destroys a vehicle with a rocket launcher.

As a result, Dragovic’s helicopter leaves without him. During a shootout between the two detectives and Dragovic’s men, Goran is killed in a fight with Vitayakul. After that, Cassidy fights with Dragovic, ultimately stabbing him in the chest, despite Dragovic commandeering a second helicopter. Dragovic tells Cassidy that Sofia is alive and was sold into the human trafficking trade. Dragovic dies from his injuries, while Cassidy gets distraught about not learning Sofia’s whereabouts. In the aftermath, Cassidy bids farewell to Vitayakul and Min, where he gives them a picture of Sofia and asks them to keep it until he finds Sofia. Cassidy sets out in search Sofia on his own.